Translocation Mapping Exposes the Risky Lifestyle of B Cells
نویسندگان
چکیده
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
منابع مشابه
A Comparison between the Effectiveness of Social-Educational Inoculation Program Based on the Islamic Approach and Stress Inoculation Training on the Lifestyle of Second-Grade High School Female Students with Risky Behavior in Yazd City
Introduction: Risky behaviors and unhealthy lifestyles are significantly associated with mortality of adolescents. So, this study was conducted to compare the effectiveness of social-educational inoculation program based on the Islamic approach and stress inoculation training on the lifestyle of second-grade high school female students with risky behaviors in Yazd. Methods: This study was semi...
متن کاملPredicting the Tendency to Risky Behaviors According to Parenting Style and Mental-Affective Atmosphere Perception of the Family with the Mediation of Healthy Life Style in the Adolescents
The purpose of the present study was to predict the tendency to risky behaviors according to parenting style and mental-affective atmosphere perception of the family with the mediation of healthy lifestyle in the adolescents. The research method was correlational in structural equations modeling type. The statistical population of the study included secondary high school students (adolescents) ...
متن کاملپیشبینی رفتار پرخطر در افراد مبتلا به HIV براساس عملکرد خانوادگی: با درنظرگرفتن متغیرهای میانجی سبک زندگی و تصمیم‌گیری پرخطر
Background and Objective: Risk behaviors are more common in the HIV-positive patients than that in the general population. These behaviors are affected by various factors, such as biological, familial, and social determinants, peer group, media, and lifestyle. Low family functioning is one of the important factors predicting risk behaviors. Regarding this, the present study aimed to investigate...
متن کاملImmunophenotyping of Nodal Peripheral T-cell Lymphomas and its Association with Epstein-Barr Virus
Background: Immunophenotyping in the rare group of nodal Peripheral T-cell Lymphomas (PTCL) exposes interesting features such as T-cell marker downregulation and paradoxically, the presence of reactive, clustered large-sized CD20 positive B-cells (B-cell proliferation). Epstein-Barr virus (EBV) has been suggested as a putative etiology in pathogenesis of B-cell lymphoma. We aimed to review the ...
متن کاملIntercellular Trafficking of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cell
دوره 147 شماره
صفحات -
تاریخ انتشار 2011